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TitleEGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 22, Page 983-990, Year 2015
Publish dateJul 31, 2015 (structure data deposition date)
AuthorsBegley, M.J. / Yun, C.H. / Gewinner, C.A. / Asara, J.M. / Johnson, J.L. / Coyle, A.J. / Eck, M.J. / Apostolou, I. / Cantley, L.C.
External linksNat. Struct. Mol. Biol. / PubMed:26551075
MethodsX-ray diffraction
Resolution2.6 - 2.8 Å
Structure data

PDB-5czh:
EGFR L858R MUTANT IN COMPLEX WITH AN OPTIMAL PEPTIDE SUBSTRATE
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-5czi:
EGFR L858R MUTANT IN COMPLEX WITH A SHC PEPTIDE SUBSTRATE
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • escherichia coli h489 (bacteria)
KeywordsTRANSFERASE / EGFR / L858R / KINASE / EGF

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