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Structure paper

TitleCrystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA.
Journal, issue, pagesBiochem. J., Vol. 473, Page 123-133, Year 2016
Publish dateNov 13, 2014 (structure data deposition date)
AuthorsMiggiano, R. / Perugino, G. / Ciaramella, M. / Serpe, M. / Rejman, D. / Pav, O. / Pohl, R. / Garavaglia, S. / Lahiri, S. / Rizzi, M. / Rossi, F.
External linksBiochem. J. / PubMed:26512127
MethodsX-ray diffraction
Resolution2.3 - 3 Å
Structure data

PDB-4wx9:
Crystal structure of Mycobacterium tuberculosis OGT in complex with DNA
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-4wxc:
Crystal structure of Mycobacterium tuberculosis OGT-Y139F
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-4wxd:
Crystal structure of Mycobacterium tuberculosis OGT-R37K
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • mycobacterium tuberculosis (bacteria)
  • synthetic construct (others)
KeywordsTRANSFERASE / direct DNA damage reversal / alkylated DNA-protein alkyltransferase / protein-DNA complex / DNA damage reversal / DNA-protein complex

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