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TitleSingle-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishes N-glycan phosphorylation in a branch-specific manner.
Journal, issue, pagesGlycobiology, Vol. 26, Page 181-192, Year 2016
Publish dateDec 19, 2014 (structure data deposition date)
AuthorsBlackler, R.J. / Evans, D.W. / Smith, D.F. / Cummings, R.D. / Brooks, C.L. / Braulke, T. / Liu, X. / Evans, S.V. / Muller-Loennies, S.
External linksGlycobiology / PubMed:26503547
MethodsX-ray diffraction
Resolution2.723 Å
Structure data

PDB-4rzc:
Fv M6P-1 in complex with mannose-6-phosphate
Method: X-RAY DIFFRACTION / Resolution: 2.723 Å

Chemicals

ChemComp-M6P:
6-O-phosphono-alpha-D-mannopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • oryctolagus cuniculus (rabbit)
KeywordsIMMUNE SYSTEM / Antibody variable fragment / mannose-6-phosphate

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