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TitleGift from Nature: Cyclomarin A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action.
Journal, issue, pagesChembiochem, Vol. 16, Page 2433-2436, Year 2015
Publish dateJul 23, 2015 (structure data deposition date)
AuthorsBurstner, N. / Roggo, S. / Ostermann, N. / Blank, J. / Delmas, C. / Freuler, F. / Gerhartz, B. / Hinniger, A. / Hoepfner, D. / Liechty, B. ...Burstner, N. / Roggo, S. / Ostermann, N. / Blank, J. / Delmas, C. / Freuler, F. / Gerhartz, B. / Hinniger, A. / Hoepfner, D. / Liechty, B. / Mihalic, M. / Murphy, J. / Pistorius, D. / Rottmann, M. / Thomas, J.R. / Schirle, M. / Schmitt, E.K.
External linksChembiochem / PubMed:26472355
MethodsX-ray diffraction
Resolution1.65 Å
Structure data

PDB-5cs2:
Crystal structure of Plasmodium falciparum diadenosine triphosphate hydrolase in complex with Cyclomarin A
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • plasmodium falciparum 3d7 (eukaryote)
  • streptomyces (bacteria)
KeywordsHYDROLASE / Cyclomarin A / diadenosine triphosphate hydrolase / anti-plasmodial activity / malaria / Plasmodium falciparum

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