EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.
ジャーナル・号・ページ	Proc Natl Acad Sci U S A, Vol. 112, Issue 43, Page E5805-E5814, Year 2015
掲載日	2015年10月27日
著者	Zohar Eyal / Donna Matzov / Miri Krupkin / Itai Wekselman / Susanne Paukner / Ella Zimmerman / Haim Rozenberg / Anat Bashan / Ada Yonath /
PubMed 要旨	The emergence of bacterial multidrug resistance to antibiotics threatens to cause regression to the preantibiotic era. Here we present the crystal structure of the large ribosomal subunit from ...The emergence of bacterial multidrug resistance to antibiotics threatens to cause regression to the preantibiotic era. Here we present the crystal structure of the large ribosomal subunit from Staphylococcus aureus, a versatile Gram-positive aggressive pathogen, and its complexes with the known antibiotics linezolid and telithromycin, as well as with a new, highly potent pleuromutilin derivative, BC-3205. These crystal structures shed light on specific structural motifs of the S. aureus ribosome and the binding modes of the aforementioned antibiotics. Moreover, by analyzing the ribosome structure and comparing it with those of nonpathogenic bacterial models, we identified some unique internal and peripheral structural motifs that may be potential candidates for improving known antibiotics and for use in the design of selective antibiotic drugs against S. aureus.
リンク	Proc Natl Acad Sci U S A / PubMed:26464510 / PubMed Central
手法	X線回折
解像度	3.392 - 3.526 Å
構造データ	PDB-4wce: The crystal structure of the large ribosomal subunit of Staphylococcus aureus 手法: X-RAY DIFFRACTION / 解像度: 3.526 Å PDB-4wf9: The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with telithromycin 手法: X-RAY DIFFRACTION / 解像度: 3.427 Å PDB-4wfa: The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with linezolid 手法: X-RAY DIFFRACTION / 解像度: 3.392 Å PDB-4wfb: The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with BC-3205 手法: X-RAY DIFFRACTION / 解像度: 3.43 Å
化合物	ChemComp-MPD: (4S)-2-METHYL-2,4-PENTANEDIOL / (S)-2-メチル-2,4-ペンタンジオ-ル / 沈殿剤YM ChemComp-MN: Unknown entry ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-EPE: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / HEPES / pH緩衝剤YM ChemComp-SPD: SPERMIDINE / スペルミジン ChemComp-EOH: ETHANOL / エタノ-ル ChemComp-TEL: TELITHROMYCIN / テリスロマイシン / 抗生剤YM ChemComp-ZLD: N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide / リネゾリド / 抗生剤YM ChemComp-NA: Unknown entry / ナトリウムカチオン ChemComp-3LK: BC-3205
由来	staphylococcus aureus (黄色ブドウ球菌) staphylococcus aureus subsp. aureus nctc 8325 (黄色ブドウ球菌) staphylococcus aureus (strain nctc 8325) (黄色ブドウ球菌) staphylococcus aureus (strain usa300) (黄色ブドウ球菌)
キーワード	RIBOSOME / RNA / bacteria