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TitleCrystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.
Journal, issue, pagesNucleic Acids Res., Vol. 43, Page 10015-10025, Year 2015
Publish dateSep 8, 2015 (structure data deposition date)
AuthorsKaminishi, T. / Schedlbauer, A. / Fabbretti, A. / Brandi, L. / Ochoa-Lizarralde, B. / He, C.G. / Milon, P. / Connell, S.R. / Gualerzi, C.O. / Fucini, P.
External linksNucleic Acids Res. / PubMed:26464437
MethodsX-ray diffraction
Resolution2.9 - 3 Å
Structure data

PDB-5dm6:
Crystal structure of the 50S ribosomal subunit from Deinococcus radiodurans
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-5dm7:
Crystal structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with hygromycin A
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-HGR:
Hygromycin A / antibiotic*YM

Source
  • deinococcus radiodurans (radioresistant)
KeywordsRIBOSOME / protein synthesis / peptidyltransferase / ribozyme / ribonucleoprotein / antibiotic / aminocyclitol

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