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TitleStructural and functional evidence for membrane docking and disruption sites on phospholipase A2-like proteins revealed by complexation with the inhibitor suramin.
Journal, issue, pagesActa Crystallogr. D Biol. Crystallogr., Vol. 71, Page 2066-2078, Year 2015
Publish dateMar 19, 2015 (structure data deposition date)
AuthorsSalvador, G.H. / Dreyer, T.R. / Cavalcante, W.L. / Matioli, F.F. / Dos Santos, J.I. / Velazquez-Campoy, A. / Gallacci, M. / Fontes, M.R.
External linksActa Crystallogr. D Biol. Crystallogr. / PubMed:26457430
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-4yv5:
Crystal Structure of Myotoxin II from Bothrops moojeni complexed to Suramin
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-PE4:
2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL / precipitant*YM

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-SVR:
8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON / medication*YM

ChemComp-HOH:
WATER

Source
  • bothrops moojeni (Brazilian lancehead)
KeywordsTOXIN / Bothrops moojeni / Myotoxin II / Lys49-PLA2 / Suramin

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