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Structure paper

TitleThe PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.
Journal, issue, pagesMol. Cell, Vol. 60, Page 319-327, Year 2015
Publish dateAug 19, 2015 (structure data deposition date)
AuthorsChen, S. / Yang, Z. / Wilkinson, A.W. / Deshpande, A.J. / Sidoli, S. / Krajewski, K. / Strahl, B.D. / Garcia, B.A. / Armstrong, S.A. / Patel, D.J. / Gozani, O.
External linksMol. Cell / PubMed:26439302
MethodsX-ray diffraction
Resolution1.6 - 2.611 Å
Structure data

PDB-5dag:
Crystal structure of PZP domain of human AF10 protein
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-5dah:
Crystal structure of PZP domain of human AF10 protein fused with Histone H3 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.611 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsPEPTIDE BINDING PROTEIN / PHD finger / histone tail reader / epigenetics / H3K27 recognition

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