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-Structure paper
Title | BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis. |
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Journal, issue, pages | Mol. Cancer Ther., Vol. 14, Page 2762-2772, Year 2015 |
Publish date | Sep 30, 2015 (structure data deposition date) |
Authors | Sanderson, M.P. / Apgar, J. / Garin-Chesa, P. / Hofmann, M.H. / Kessler, D. / Quant, J. / Savchenko, A. / Schaaf, O. / Treu, M. / Tye, H. ...Sanderson, M.P. / Apgar, J. / Garin-Chesa, P. / Hofmann, M.H. / Kessler, D. / Quant, J. / Savchenko, A. / Schaaf, O. / Treu, M. / Tye, H. / Zahn, S.K. / Zoephel, A. / Haaksma, E. / Adolf, G.R. / Kraut, N. |
External links | Mol. Cancer Ther. / PubMed:26438154 |
Methods | X-ray diffraction |
Resolution | 2.264 Å |
Structure data | PDB-5e1s: |
Chemicals | ChemComp-5JA: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / Kinase / INSR / IGF-1R / Inhibitor |