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TitleRational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target NaV1.7
Journal, issue, pagesMol. Pharmacol., Vol. 88, Page 1002-1010, Year 2015
Publish dateJun 19, 2014 (structure data deposition date)
AuthorsKlint, J.K. / Chin, Y.K. / Mobli, M.
External linksMol. Pharmacol. / PubMed:26429937
MethodsNMR (solution)
Structure data

PDB-2mqf:
NMR structure of spider toxin-TRTX-Hhn2b
Method: SOLUTION NMR

PDB-2mxo:
NMR structure of spider toxin- G7W/N24S mutant of TRTX-Hhn2b
Method: SOLUTION NMR

Source
  • haplopelma hainanum (spider)
KeywordsTOXIN / Spider toxin / Voltage gated ion channel / NaV1.7

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