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TitleMediator Kinase Inhibition Further Activates Super-Enhancer- Associated Genes in Aml
Journal, issue, pagesNature, Vol. 526, Page 273-, Year 2015
Publish dateFeb 27, 2014 (structure data deposition date)
AuthorsPelish, H.E. / Liau, B.B. / Nitulescu, I.I. / Tangpeerachaikul, A. / Poss, Z.C. / Da Silva, D.H. / Caruso, B.T. / Arefolov, A. / Fadeyi, O. / Christie, A.L. ...Pelish, H.E. / Liau, B.B. / Nitulescu, I.I. / Tangpeerachaikul, A. / Poss, Z.C. / Da Silva, D.H. / Caruso, B.T. / Arefolov, A. / Fadeyi, O. / Christie, A.L. / Du, K. / Banka, D. / Schneider, E.V. / Jestel, A. / Zou, G. / Si, C. / Ebmeier, C.C. / Bronson, R.T. / Krivtsov, A.V. / Myers, A.G. / Kohl, N.E. / Kung, A.L. / Armstrong, S.A. / Lemieux, M.E. / Taatjes, D.J. / Shair, M.D.
External linksNature / PubMed:26416749
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-4crl:
Crystal structure of human CDK8-Cyclin C in complex with cortistatin A
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-C1I:
CORTISTATIN A / inhibitor, alkaloid*YM

ChemComp-FMT:
FORMIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / CYCLIN-DEPENDENT KINASE 8 / CDK8 / CYCLIN C / CCNC / CORTISTATIN A / MEDIATOR KINASE / MEDIATOR COMPLEX / SUPER-ENHANCER / TRANSCRIPTION

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