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Structure paper

TitleMolecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody.
Journal, issue, pagesMabs, Vol. 8, Page 176-186, Year 2016
Publish dateJun 25, 2015 (structure data deposition date)
AuthorsEylenstein, R. / Weinfurtner, D. / Hartle, S. / Strohner, R. / Bottcher, J. / Augustin, M. / Ostendorp, R. / Steidl, S.
External linksMabs / PubMed:26406987
MethodsX-ray diffraction
Resolution1.88 - 2.95 Å
Structure data

PDB-5c7x:
Crystal structure of MOR04357, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

PDB-5d70:
Crystal structure of MOR03929, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

PDB-5d71:
Crystal structure of MOR04302, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-5d72:
Crystal structure of MOR04252, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-5d7s:
Crystal structure of MOR04357, a neutralizing anti-human GM-CSF antibody Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 1.88 Å

Chemicals

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-PG6:
1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-BUD:
(2S,3S)-butane-2,3-diol

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / GM-CSF / affinity maturation / phage display / cytokine / antibody / PROTEROS BIOSTRUCTURES GMBH

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