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Structure paper

TitleAtomic description of the immune complex involved in heparin-induced thrombocytopenia.
Journal, issue, pagesNat Commun, Vol. 6, Page 8277-8277, Year 2015
Publish dateSep 3, 2014 (structure data deposition date)
AuthorsCai, Z. / Yarovoi, S.V. / Zhu, Z. / Rauova, L. / Hayes, V. / Lebedeva, T. / Liu, Q. / Poncz, M. / Arepally, G. / Cines, D.B. / Greene, M.I.
External linksNat Commun / PubMed:26391892
MethodsX-ray diffraction
Resolution2.2 - 4.11 Å
Structure data

PDB-4r97:
Crystal structure of the Fab fragment of KKO
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-4r9w:
Crystal structure of platelet factor 4 complexed with fondaparinux
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-4r9y:
Crystal structure of KKOFab in complex with platelet factor 4
Method: X-RAY DIFFRACTION / Resolution: 4.11 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / IMMUNOGLOBULIN / CYTOKINE / PF4 / fondaparinux / CXC chemokine / platelet factor / glycosaminoglycan / platelet / IMMUNE SYSTEM/Cytokine / KKO / HIT / antibody / antigen / blood / IMMUNE SYSTEM-Cytokine complex

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