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Title | Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. |
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Journal, issue, pages | Chemmedchem, Vol. 10, Page 1884-1891, Year 2015 |
Publish date | Aug 28, 2015 (structure data deposition date) |
![]() | Marzinzik, A.L. / Amstutz, R. / Bold, G. / Bourgier, E. / Cotesta, S. / Glickman, J.F. / Gotte, M. / Henry, C. / Lehmann, S. / Hartwieg, J.C. ...Marzinzik, A.L. / Amstutz, R. / Bold, G. / Bourgier, E. / Cotesta, S. / Glickman, J.F. / Gotte, M. / Henry, C. / Lehmann, S. / Hartwieg, J.C. / Ofner, S. / Pelle, X. / Roddy, T.P. / Rondeau, J.M. / Stauffer, F. / Stout, S.J. / Widmer, A. / Zimmermann, J. / Zoller, T. / Jahnke, W. |
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Methods | X-ray diffraction |
Resolution | 2.08 - 2.4 Å |
Structure data | ![]() PDB-5dgn: ![]() PDB-5diq: ![]() PDB-5djp: ![]() PDB-5djr: ![]() PDB-5djv: |
Chemicals | ![]() ChemComp-59Y: ![]() ChemComp-HOH: ![]() ChemComp-GOL: ![]() ChemComp-5B9: ![]() ChemComp-MG: ![]() ChemComp-PO4: ![]() ChemComp-5BJ: ![]() ChemComp-5BK: ![]() ChemComp-5BL: |
Source |
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