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Structure paper

TitleCrystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1
Journal, issue, pagesJ. Biol. Chem., Vol. 290, Page 25795-25804, Year 2015
Publish dateJun 1, 2015 (structure data deposition date)
AuthorsGong, L. / Liu, M. / Zeng, T. / Shi, X. / Yuan, C. / Andreasen, P.A. / Huang, M.
External linksJ. Biol. Chem. / PubMed:26324706
MethodsX-ray diffraction
Resolution3.16 Å
Structure data

PDB-5brr:
Michaelis complex of tPA-S195A:PAI-1
Method: X-RAY DIFFRACTION / Resolution: 3.16 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE INHIBITOR/HYDROLASE / Tissue-Type Plasminogen Activator Catalytic Domain / Plasminogen Activator Inhibitor 1 / Structure-Activity Relationship / Thrombolysis / HYDROLASE INHIBITOR-HYDROLASE complex

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