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-Structure paper
Title | Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase Gamma for the Treatment of Respiratory Disease. |
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Journal, issue, pages | J. Med. Chem., Vol. 58, Page 7381-, Year 2015 |
Publish date | Aug 26, 2015 (structure data deposition date) |
Authors | Down, K. / Amour, A. / Baldwin, I.R. / Cooper, A.W.J. / Deakin, A.M. / Felton, L.M. / Guntrip, S.B. / Hardy, C. / Harrison, Z.A. / Jones, K.L. ...Down, K. / Amour, A. / Baldwin, I.R. / Cooper, A.W.J. / Deakin, A.M. / Felton, L.M. / Guntrip, S.B. / Hardy, C. / Harrison, Z.A. / Jones, K.L. / Jones, P. / Keeling, S.E. / Le, J. / Livia, S. / Lucas, F. / Lunniss, C.J. / Parr, N.J. / Robinson, E. / Rowland, P. / Smith, S. / Thomas, D.A. / Vitulli, G. / Washio, Y. / Hamblin, J.N. |
External links | J. Med. Chem. / PubMed:26301626 |
Methods | X-ray diffraction |
Resolution | 2.42 - 2.44 Å |
Structure data | PDB-5ae8: PDB-5ae9: |
Chemicals | ChemComp-VVX: ChemComp-HOH: ChemComp-OKO: |
Source |
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Keywords | TRANSFERASE / PI3 KINASE DELTA |