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TitleImpaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of Thr-592.
Journal, issue, pagesJ. Biol. Chem., Vol. 290, Page 26352-26359, Year 2015
Publish dateMay 19, 2015 (structure data deposition date)
AuthorsTang, C. / Ji, X. / Wu, L. / Xiong, Y.
External linksJ. Biol. Chem. / PubMed:26294762
MethodsX-ray diffraction
Resolution2.3 - 2.81 Å
Structure data

PDB-4zwe:
Crystal structure of the dGTP-bound catalytic core of SAMHD1 T592V mutant
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

PDB-4zwg:
Crystal structure of the GTP-dATP-bound catalytic core of SAMHD1 phosphomimetic T592E mutant
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-DGT:
2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-DTP:
2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Phosphorylation / Tetramer stability / dNTPase / HIV-1 Restriction

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