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Structure paper

TitleAllosteric transcriptional regulation via changes in the overall topology of the core promoter.
Journal, issue, pagesScience, Vol. 349, Page 877-881, Year 2015
Publish dateOct 8, 2014 (structure data deposition date)
AuthorsPhilips, S.J. / Canalizo-Hernandez, M. / Yildirim, I. / Schatz, G.C. / Mondragon, A. / O'Halloran, T.V.
External linksScience / PubMed:26293965
MethodsX-ray diffraction
Resolution2.105 - 2.8 Å
Structure data

PDB-4wls:
Crystal structure of the metal-free (repressor) form of E. Coli CUER, a copper efflux regulator, bound to COPA promoter DNA
Method: X-RAY DIFFRACTION / Resolution: 2.105 Å

PDB-4wlw:
CRYSTAL STRUCTURE OF THE AG(I) (ACTIVATOR) FORM OF E. COLI CUER, A COPPER EFFLUX REGULATOR, BOUND TO COPA PROMOTER DNA
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-AG:
SILVER ION

Source
  • escherichia coli dh5[alpha] (bacteria)
  • synthetic construct (others)
  • escherichia coli (E. coli)
KeywordsTranscription Regulator/DNA / PROTEIN-DNA COMPLEX / MERR-FAMILY TRANSCRIPTION REGULATOR / METAL-FREE FORM / REPRESSOR / TRANSCRIPTION / Transcription Regulator-DNA complex / TRANSCRIPTION/DNA / AG(I)FORM / ACTIVATOR / TRANSCRIPTION-DNA complex

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