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TitleDevelopment of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.
Journal, issue, pagesJ. Med. Chem., Vol. 58, Page 6928-6937, Year 2015
Publish dateDec 8, 2014 (structure data deposition date)
AuthorsBorisek, J. / Vizovisek, M. / Sosnowski, P. / Turk, B. / Turk, D. / Mohar, B. / Novic, M.
External linksJ. Med. Chem. / PubMed:26280490
MethodsX-ray diffraction
Resolution1 - 1.87 Å
Structure data

PDB-4x6h:
Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.
Method: X-RAY DIFFRACTION / Resolution: 1 Å

PDB-4x6i:
Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.
Method: X-RAY DIFFRACTION / Resolution: 1.87 Å

PDB-4x6j:
Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.
Method: X-RAY DIFFRACTION / Resolution: 1.59 Å

Chemicals

ChemComp-3XT:
4-amino-3-fluoro-N-(1-{[(2Z)-2-iminoethyl]carbamoyl}cyclohexyl)benzamide

ChemComp-I37:
4-amino-N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-3-fluorobenzamide

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-3Y1:
2-amino-4-bromo-N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}benzamide

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-PGO:
S-1,2-PROPANEDIOL

ChemComp-3Y2:
2-amino-4-chloro-N-(1-{[(2E)-2-iminoethyl]carbamoyl}cyclohexyl)benzamide

Source
  • homo sapiens (human)
KeywordsHYDROLASE / cathepsin K / inhibitor

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