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TitlePlatinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding.
Journal, issue, pagesInorg. Chem., Vol. 54, Page 8560-8570, Year 2015
Publish dateMar 31, 2015 (structure data deposition date)
AuthorsMugge, C. / Marzo, T. / Massai, L. / Hildebrandt, J. / Ferraro, G. / Rivera-Fuentes, P. / Metzler-Nolte, N. / Merlino, A. / Messori, L. / Weigand, W.
External linksInorg. Chem. / PubMed:26280387
MethodsX-ray diffraction
Resolution1.89 - 2.15 Å
Structure data

PDB-4z3m:
X-ray structure of the adduct formed in the reaction between lysozyme and a platinum(II) Complex with S,O Bidentate Ligands (9b)
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-4z41:
X-ray structure of the adduct formed in the reaction between lysozyme and a platinum(II) Compound with a S,O Bidentate Ligand (9a=Chloro-(1-(3'-hydroxy)-3-(methylthio)-3-thioxo-prop-1-en-1-olate-O,S)-(dimethylsulfoxide-S)-platinum(II))
Method: X-RAY DIFFRACTION / Resolution: 1.89 Å

Chemicals

ChemComp-4KV:
3-[2-chloranyl-2-[dimethyl(oxidanyl)-{4}-sulfanyl]-4-ethylsulfanyl-1-oxa-3{3}-thia-2{4}-platinacyclohexa-3,5-dien-6-yl]phenol

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-NO3:
NITRATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • gallus gallus (chicken)
KeywordsHYDROLASE / Pt compounds / anticancer agents / lysozyme complexes

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