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TitleTotal Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1
Journal, issue, pagesJ. Nat. Prod., Vol. 78, Page 1969-1976, Year 2015
Publish dateJan 5, 2015 (structure data deposition date)
AuthorsChao, S.-W. / Su, M.-Y. / Chiou, L.-C. / Chen, L.-C. / Chang, C.-I. / Huang, W.-J.
External linksJ. Nat. Prod. / PubMed:26275107
MethodsX-ray diffraction
Resolution2.04 Å
Structure data

PDB-4xh6:
Crystal structure of proto-oncogene kinase Pim1 bound to hispidulin
Method: X-RAY DIFFRACTION / Resolution: 2.04 Å

Chemicals

ChemComp-HUL:
5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase Inhibitor / Pim1 / Hispidulin / inhibitor / kinase / Transferase-Transferase Inhibitor complex

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