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TitleStructural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics.
Journal, issue, pagesNucleic Acids Res., Vol. 43, Page 8601-8613, Year 2015
Publish dateApr 15, 2015 (structure data deposition date)
AuthorsShalev, M. / Rozenberg, H. / Smolkin, B. / Nasereddin, A. / Kopelyanskiy, D. / Belakhov, V. / Schrepfer, T. / Schacht, J. / Jaffe, C.L. / Adir, N. / Baasov, T.
External linksNucleic Acids Res. / PubMed:26264664
MethodsX-ray diffraction
Resolution3.041 Å
Structure data

PDB-4zc7:
Paromomycin bound to a leishmanial ribosomal A-site
Method: X-RAY DIFFRACTION / Resolution: 3.041 Å

Chemicals

ChemComp-PAR:
PAROMOMYCIN / Antimicrobial, medication*YM

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
KeywordsRNA / A-site / ribosome / paromomycin / Leishmania

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