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TitleCrystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing.
Journal, issue, pagesJ Immunol., Vol. 195, Page 2842-2851, Year 2015
Publish dateApr 7, 2015 (structure data deposition date)
AuthorsMpakali, A. / Saridakis, E. / Harlos, K. / Zhao, Y. / Papakyriakou, A. / Kokkala, P. / Georgiadis, D. / Stratikos, E.
External linksJ Immunol. / PubMed:26259583
MethodsX-ray diffraction
Resolution3.31 - 3.37 Å
Structure data

PDB-4z7i:
Crystal structure of insulin regulated aminopeptidase in complex with ligand
Method: X-RAY DIFFRACTION / Resolution: 3.31 Å

PDB-5c97:
Insulin regulated aminopeptidase
Method: X-RAY DIFFRACTION / Resolution: 3.37 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsHYDROLASE / aminopeptidase / antigen presentation / transition-state analogue / enzyme inhibitor / IRAP

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