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TitleDisruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Journal, issue, pagesEmbo J., Vol. 34, Page 2506-2521, Year 2015
Publish dateJun 15, 2015 (structure data deposition date)
AuthorsKumar, A. / Aguirre, J.D. / Condos, T.E. / Martinez-Torres, R.J. / Chaugule, V.K. / Toth, R. / Sundaramoorthy, R. / Mercier, P. / Knebel, A. / Spratt, D.E. ...Kumar, A. / Aguirre, J.D. / Condos, T.E. / Martinez-Torres, R.J. / Chaugule, V.K. / Toth, R. / Sundaramoorthy, R. / Mercier, P. / Knebel, A. / Spratt, D.E. / Barber, K.R. / Shaw, G.S. / Walden, H.
External linksEmbo J. / PubMed:26254304
MethodsX-ray diffraction
Resolution1.79 - 2.37 Å
Structure data

PDB-5c1z:
Parkin (UblR0RBR)
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

PDB-5c23:
Parkin (S65DUblR0RBR)
Method: X-RAY DIFFRACTION / Resolution: 2.37 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / E3 ligase2

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