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TitleUnsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3 alpha.
Journal, issue, pagesSci Rep, Vol. 5, Page 12698-12698, Year 2015
Publish dateOct 10, 2014 (structure data deposition date)
AuthorsFala, A.M. / Oliveira, J.F. / Adamoski, D. / Aricetti, J.A. / Dias, M.M. / Dias, M.V.B. / Sforca, M.L. / Lopes-de-Oliveira, P.S. / Rocco, S.A. / Caldana, C. ...Fala, A.M. / Oliveira, J.F. / Adamoski, D. / Aricetti, J.A. / Dias, M.M. / Dias, M.V.B. / Sforca, M.L. / Lopes-de-Oliveira, P.S. / Rocco, S.A. / Caldana, C. / Dias, S.M.G. / Ambrosio, A.L.B.
External linksSci Rep / PubMed:26237540
MethodsX-ray diffraction
Resolution1.15 Å
Structure data

PDB-4wn5:
Crystal structure of the C-terminal Per-Arnt-Sim (PASb) of human HIF-3alpha9 bound to 18:1-1-monoacylglycerol
Method: X-RAY DIFFRACTION / Resolution: 1.15 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-MVC:
MONOVACCENIN

ChemComp-P6G:
HEXAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / HIF-3alpha / PAS domain / monoacylglycerol / lipid / fatty acid

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