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Structure paper

TitleChemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions.
Journal, issue, pagesNat Commun, Vol. 6, Page 7896-7896, Year 2015
Publish dateOct 15, 2014 (structure data deposition date)
AuthorsWasserman, M.R. / Pulk, A. / Zhou, Z. / Altman, R.B. / Zinder, J.C. / Green, K.D. / Garneau-Tsodikova, S. / Doudna Cate, J.H. / Blanchard, S.C.
External linksNat Commun / PubMed:26224058
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-4woi:
4,5-linked aminoglycoside antibiotics regulate the bacterial ribosome by targeting dynamic conformational processes within intersubunit bridge B2
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-PAR:
PAROMOMYCIN / Antimicrobial, medication*YM

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • escherichia coli str. k-12 substr. mds42 (bacteria)
  • escherichia coli (E. coli)
  • thermus thermophilus (bacteria)
  • enterobacteria phage l1 (virus)
KeywordsRIBOSOME / Protein biosynthesis / ribosomes / paromomycin / antibiotic translocation / RNA / tRNA / transfer / exit / peptidyl / 30S / 70S / 16S / ribosomal subunit

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