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Structure paper

TitleStructure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 22, Page 627-635, Year 2015
Publish dateMay 27, 2015 (structure data deposition date)
AuthorsVolkers, G. / Worrall, L.J. / Kwan, D.H. / Yu, C.C. / Baumann, L. / Lameignere, E. / Wasney, G.A. / Scott, N.E. / Wakarchuk, W. / Foster, L.J. ...Volkers, G. / Worrall, L.J. / Kwan, D.H. / Yu, C.C. / Baumann, L. / Lameignere, E. / Wasney, G.A. / Scott, N.E. / Wakarchuk, W. / Foster, L.J. / Withers, S.G. / Strynadka, N.C.
External linksNat. Struct. Mol. Biol. / PubMed:26192331
MethodsX-ray diffraction
Resolution1.85 - 2.7 Å
Structure data

PDB-5bo6:
Structure of human sialyltransferase ST8SiaIII in complex with CDP
Method: X-RAY DIFFRACTION / Resolution: 2.07 Å

PDB-5bo7:
Structure of human sialyltransferase ST8SiaIII in complex with CTP
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-5bo8:
Structure of human sialyltransferase ST8SiaIII
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-5bo9:
Structure of human sialyltransferase ST8SiaIII in complex with CMP-3FNeu5Ac and Sia-6S-LacNAc
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-CDP:
CYTIDINE-5'-DIPHOSPHATE

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-CTP:
CYTIDINE-5'-TRIPHOSPHATE

ChemComp-CIT:
CITRIC ACID

ChemComp-CSF:
CYTIDINE-5'-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC ACID

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / sialyltransferase / CDP / CTP / ternary complex / donor / acceptor

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