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-Structure paper
Title | A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. |
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Journal, issue, pages | Sci Transl Med, Vol. 7, Page 296ra111-296ra111, Year 2015 |
Publish date | Dec 8, 2014 (structure data deposition date) |
Authors | Phillips, M.A. / Lotharius, J. / Marsh, K. / White, J. / Dayan, A. / White, K.L. / Njoroge, J.W. / El Mazouni, F. / Lao, Y. / Kokkonda, S. ...Phillips, M.A. / Lotharius, J. / Marsh, K. / White, J. / Dayan, A. / White, K.L. / Njoroge, J.W. / El Mazouni, F. / Lao, Y. / Kokkonda, S. / Tomchick, D.R. / Deng, X. / Laird, T. / Bhatia, S.N. / March, S. / Ng, C.L. / Fidock, D.A. / Wittlin, S. / Lafuente-Monasterio, M. / Benito, F.J. / Alonso, L.M. / Martinez, M.S. / Jimenez-Diaz, M.B. / Bazaga, S.F. / Angulo-Barturen, I. / Haselden, J.N. / Louttit, J. / Cui, Y. / Sridhar, A. / Zeeman, A.M. / Kocken, C. / Sauerwein, R. / Dechering, K. / Avery, V.M. / Duffy, S. / Delves, M. / Sinden, R. / Ruecker, A. / Wickham, K.S. / Rochford, R. / Gahagen, J. / Iyer, L. / Riccio, E. / Mirsalis, J. / Bathhurst, I. / Rueckle, T. / Ding, X. / Campo, B. / Leroy, D. / Rogers, M.J. / Rathod, P.K. / Burrows, J.N. / Charman, S.A. |
External links | Sci Transl Med / PubMed:26180101 |
Methods | X-ray diffraction |
Resolution | 2.25 - 2.8 Å |
Structure data | PDB-4rx0: PDB-5boo: |
Chemicals | ChemComp-D65: ChemComp-FMN: ChemComp-ORO: ChemComp-GOL: ChemComp-HOH: |
Source |
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Keywords | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / alpha/beta barrel / oxidoreductase / FM / mitochondrial membrane / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex / OXIDOREDUCTASE/INHIBITOR / redox / dehydrogenase / FMN / inhibitor / OXIDOREDUCTASE-INHIBITOR complex |