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TitleIdentification of a Class of Protein Adp-Ribosylating Sirtuins in Microbial Pathogens.
Journal, issue, pagesMol. Cell, Vol. 59, Page 309-, Year 2015
Publish dateMay 27, 2015 (structure data deposition date)
AuthorsRack, J.G. / Morra, R. / Barkauskaite, E. / Kraehenbuehl, R. / Ariza, A. / Qu, Y. / Ortmayer, M. / Leidecker, O. / Cameron, D.R. / Matic, I. ...Rack, J.G. / Morra, R. / Barkauskaite, E. / Kraehenbuehl, R. / Ariza, A. / Qu, Y. / Ortmayer, M. / Leidecker, O. / Cameron, D.R. / Matic, I. / Peleg, A.Y. / Leys, D. / Traven, A. / Ahel, I.
External linksMol. Cell / PubMed:26166706
MethodsX-ray diffraction
Resolution1.5 - 2.03 Å
Structure data

PDB-5a35:
Crystal structure of Glycine Cleavage Protein H-Like (GcvH-L) from Streptococcus pyogenes
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-5a3a:
Crystal structure of the ADP-ribosylating sirtuin (SirTM) from Streptococcus pyogenes (Apo form)
Method: X-RAY DIFFRACTION / Resolution: 1.54 Å

PDB-5a3b:
Crystal structure of the ADP-ribosylating sirtuin (SirTM) from Streptococcus pyogenes in complex with ADP-ribose
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-5a3c:
Crystal structure of the ADP-ribosylating sirtuin (SirTM) from Streptococcus pyogenes in complex with NAD
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

Chemicals

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-GLY:
GLYCINE

ChemComp-ZN:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ALA:
ALANINE

ChemComp-APR:
ADENOSINE-5-DIPHOSPHORIBOSE

ChemComp-NAD:
NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NAD*YM

Source
  • streptococcus pyogenes (bacteria)
KeywordsTRANSPORT PROTEIN / LIPOYLATION / ADP-RIBOSYLATION / TRANSFERASE / P-RIBOSYLTRANSFERASE / METALLOPROTEIN / NAD-DEPENDENT / REGULATORY ENZYME / ROSSMANN FOLD / ZINC BINDING / ROS DEFENSE / ADP-RIBOSYLTRANSFERASE

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