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-Structure paper
タイトル | Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. |
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ジャーナル・号・ページ | Plos One, Vol. 10, Page 32004-, Year 2015 |
掲載日 | 2015年6月3日 (構造データの登録日) |
著者 | Chan, M.C. / Atasoylu, O. / Hodson, E. / Tumber, A. / Leung, I.K.H. / Chowdhury, R. / Gomez-Perez, V. / Demetriades, M. / Rydzik, A.M. / Holt-Martyn, J. ...Chan, M.C. / Atasoylu, O. / Hodson, E. / Tumber, A. / Leung, I.K.H. / Chowdhury, R. / Gomez-Perez, V. / Demetriades, M. / Rydzik, A.M. / Holt-Martyn, J. / Tian, Y. / Bishop, T. / Claridge, T.D.W. / Kawamura, A. / Pugh, C.W. / Ratcliffe, P.J. / Schofield, C.J. |
リンク | Plos One / PubMed:26147748 |
手法 | X線回折 |
解像度 | 3.3 Å |
構造データ | PDB-5a3u: |
化合物 | ChemComp-MN: ChemComp-R8J: |
由来 |
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キーワード | OXIDOREDUCTASE / NON-HEME / IRON / 2-OXOGLUTARATE / DIOXYGENASE / HYPOXIA-INDUCIBLE FACTOR / HIF / HIF PROLYL HYDROXYLASE DOMAIN 2 / PHD2 / EGLN / OXYGENASE / HYPOXIA / DNA-BINDING / METAL-BINDING / TRANSCRIPTION / HELIX-LOOP-HELIX-BETA / DSBH / FACIAL TRIAD / ASPARAGINYL/ ASPARTYL HYDROXYLASE / TRANSCRIPTION AND EPIGENETIC REGULATION / SIGNALING / DEVELOPMENT / CELL STRUCTURE / ANKYRIN REPEAT DOMAIN / ARD / BETA-HYDROXYLATION / TRANSCRIPTION ACTIVATOR/INHIBITOR / PHOSPHORYLATION / S-NITROSYLATION |