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TitleHIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry.
Journal, issue, pagesJ. Virol., Vol. 89, Page 9068-9079, Year 2015
Publish dateJan 21, 2015 (structure data deposition date)
AuthorsZhou, J. / Price, A.J. / Halambage, U.D. / James, L.C. / Aiken, C.
External linksJ. Virol. / PubMed:26109731
MethodsX-ray diffraction
Resolution1.95 - 2.01 Å
Structure data

PDB-4xro:
Disulfide stabilized HIV-1 CA hexamer 4mut (S41A, Q67H, V165I, L172I)
Method: X-RAY DIFFRACTION / Resolution: 2.01 Å

PDB-4xrq:
Disulfide stabilized HIV-1 CA hexamer 4mut (S41A, Q67H, V165I, L172I) in complex with PF-3450074
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-1B0:
N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE

Source
  • human immunodeficiency virus type 1 group m subtype b (isolate ny5)
  • human immunodeficiency virus 1
KeywordsVIRAL PROTEIN / capsid / inhibitor

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