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Structure paper

TitleThe Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study
Journal, issue, pagesEbiomedicine, Vol. 2, Page 194-, Year 2015
Publish dateAug 15, 2014 (structure data deposition date)
AuthorsBunney, T. / Wan, S. / Thiyagarajan, N. / Sutto, L. / Williams, S.V. / Ashford, P. / Koss, H. / Knowles, M.A. / Gervasio, F.L. / Coveney, P.V. / Katan, M.
External linksEbiomedicine / PubMed:26097890
MethodsX-ray diffraction
Resolution1.957 - 2.305 Å
Structure data

PDB-4uwy:
FGFR1 Apo structure
Method: X-RAY DIFFRACTION / Resolution: 2.305 Å

PDB-5am6:
Native FGFR1 with an inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

PDB-5am7:
FGFR1 mutant with an inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.957 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-38O:
4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / INHIBITOR / DRUG / CANCER / FGF / RECEPTORS / GROWTH FACTORS / SIGNALLING / FGFR / GROWTH FACTOR / DOVITINIB / TKI258 / KINASE / GATEKEEPER / GATE KEEPER

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