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TitleDeep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration.
Journal, issue, pagesJ. Biol. Chem., Vol. 290, Page 21773-21786, Year 2015
Publish dateApr 21, 2015 (structure data deposition date)
AuthorsKoenig, P. / Lee, C.V. / Sanowar, S. / Wu, P. / Stinson, J. / Harris, S.F. / Fuh, G.
External linksJ. Biol. Chem. / PubMed:26088137
MethodsX-ray diffraction
Resolution2.27 - 2.75 Å
Structure data

PDB-4zff:
Dual-acting Fab 5A12 in complex with VEGF
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-4zfg:
Dual-specificity Fab 5A12 in complex with Angiopoietin 2
Method: X-RAY DIFFRACTION / Resolution: 2.27 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-CA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN/IMMUNE SYSTEM / Fab / DAF / angiogenesis / Tie receptor / SIGNALING PROTEIN-IMMUNE SYSTEM complex

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