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TitleCocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1.
Journal, issue, pagesJ. Virol., Vol. 89, Page 8840-8854, Year 2015
Publish dateSep 25, 2014 (structure data deposition date)
AuthorsGohain, N. / Tolbert, W.D. / Acharya, P. / Yu, L. / Liu, T. / Zhao, P. / Orlandi, C. / Visciano, M.L. / Kamin-Lewis, R. / Sajadi, M.M. ...Gohain, N. / Tolbert, W.D. / Acharya, P. / Yu, L. / Liu, T. / Zhao, P. / Orlandi, C. / Visciano, M.L. / Kamin-Lewis, R. / Sajadi, M.M. / Martin, L. / Robinson, J.E. / Kwong, P.D. / DeVico, A.L. / Ray, K. / Lewis, G.K. / Pazgier, M.
External linksJ. Virol. / PubMed:26085162
MethodsX-ray diffraction
Resolution1.91 - 3.21 Å
Structure data

PDB-4rfe:
Crystal structure of ADCC-potent ANTI-HIV-1 Rhesus macaque antibody JR4 Fab
Method: X-RAY DIFFRACTION / Resolution: 1.91 Å

PDB-4rfn:
Crystal structure of ADCC-potent Rhesus macaque ANTIBODY JR4 in complex with HIV-1 CLADE A/E GP120 and M48
Method: X-RAY DIFFRACTION / Resolution: 3.21 Å

PDB-4rfo:
Crystal structure of the ADCC-Potent Antibody N60-I3 Fab in complex with HIV-1 Clade A/E gp120 and M48u1
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • macaca mulatta (Rhesus monkey)
  • human immunodeficiency virus 1
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / HIV-1 GP120 SPECIFIC ANTIBODY / CD4I ANTIBODY / ADCC / HIV-1 ENV / ANTI-HIV-1 ENV ANTIBODY JR4 / VIRAL PROTEIN/IMMUNE SYSTEM / HIV-1 GP120 / VIRAL PROTEIN / VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX / VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR / CLADE A/E 93TH057 / VIRAL PROTEIN-IMMUNE SYSTEM-INHIBITOR complex

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