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Title | Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. |
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Journal, issue, pages | J. Biol. Chem., Vol. 290, Page 20044-20059, Year 2015 |
Publish date | Apr 28, 2014 (structure data deposition date) |
![]() | Durham, T.B. / Toth, J.L. / Klimkowski, V.J. / Cao, J.X. / Siesky, A.M. / Alexander-Chacko, J. / Wu, G.Y. / Dixon, J.T. / McGee, J.E. / Wang, Y. ...Durham, T.B. / Toth, J.L. / Klimkowski, V.J. / Cao, J.X. / Siesky, A.M. / Alexander-Chacko, J. / Wu, G.Y. / Dixon, J.T. / McGee, J.E. / Wang, Y. / Guo, S.Y. / Cavitt, R.N. / Schindler, J. / Thibodeaux, S.J. / Calvert, N.A. / Coghlan, M.J. / Sindelar, D.K. / Christe, M. / Kiselyov, V.V. / Michael, M.D. / Sloop, K.W. |
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Methods | X-ray diffraction |
Resolution | 2.21 - 2.5 Å |
Structure data | ![]() PDB-4pf7: ![]() PDB-4pf9: ![]() PDB-4pfc: |
Chemicals | ![]() ChemComp-2QW: ![]() ChemComp-ZN: ![]() ChemComp-HOH: ![]() ChemComp-2Q6: ![]() ChemComp-2QX: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR complex |