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TitleStructure-Based Design of gamma-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors.
Journal, issue, pagesJ. Med. Chem., Vol. 58, Page 4927-4939, Year 2015
Publish dateApr 9, 2015 (structure data deposition date)
AuthorsRan, X. / Zhao, Y. / Liu, L. / Bai, L. / Yang, C.Y. / Zhou, B. / Meagher, J.L. / Chinnaswamy, K. / Stuckey, J.A. / Wang, S.
External linksJ. Med. Chem. / PubMed:26080064
MethodsX-ray diffraction
Resolution1.27 Å
Structure data

PDB-4z93:
BRD4 bromodomain 2 in complex with gamma-carboline-containing compound, number 18.
Method: X-RAY DIFFRACTION / Resolution: 1.27 Å

Chemicals

ChemComp-4LD:
1-(3-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-8-methoxy-5H-pyrido[4,3-b]indole

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Bromodomain

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