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TitleAnion-Dependent Stimulation of Cyp3A4 Monooxygenase.
Journal, issue, pagesBiochemistry, Vol. 54, Page 4083-, Year 2015
Publish dateMay 4, 2015 (structure data deposition date)
AuthorsSevrioukova, I.F. / Poulos, T.L.
External linksBiochemistry / PubMed:26066995
MethodsX-ray diffraction
Resolution2.45 - 2.5 Å
Structure data

PDB-5a1p:
Crystal structure of cytochrome P450 3A4 bound to progesterone and citrate
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-5a1r:
Crystal structure of cytochrome P450 3A4 bound to progesterone
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-STR:
PROGESTERONE / hormone*YM

ChemComp-CIT:
CITRIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / CYTOCHROME P450 3A4 / CYP3A4 / MONOOXYGENASE / PROGESTERONE / CITRATE

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