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TitleCrystallization of interleukin-18 for structure-based inhibitor design.
Journal, issue, pagesActa Crystallogr. ,Sect. F, Vol. 71, Page 710-717, Year 2015
Publish dateDec 28, 2014 (structure data deposition date)
AuthorsKrumm, B. / Meng, X. / Xiang, Y. / Deng, J.
External linksActa Crystallogr. ,Sect. F / PubMed:26057800
MethodsX-ray diffraction
Resolution1.91 - 2.85 Å
Structure data

PDB-4xfs:
Structure of IL-18 SER Mutant I
Method: X-RAY DIFFRACTION / Resolution: 1.91 Å

PDB-4xft:
Structure of IL-18 SER Mutant III
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-4xfu:
Structure of IL-18 SER Mutant V
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCYTOKINE / Interleukin-18 / IL-18 / immune defense / surface entropy reduction

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