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Structure paper

TitleStructural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase
Journal, issue, pagesEMBO J., Vol. 34, Page 1959-, Year 2015
Publish dateMay 15, 2015 (structure data deposition date)
AuthorsSzymanski, M.R. / Kuznestov, V.B. / Shumate, C.K. / Meng, Q. / Lee, Y.-S. / Patel, G. / Patel, S.S. / Yin, Y.W.
External linksEMBO J. / PubMed:26056153
MethodsX-ray diffraction
Resolution3.299 - 3.442 Å
Structure data

PDB-4ztu:
Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase
Method: X-RAY DIFFRACTION / Resolution: 3.299 Å

PDB-4ztz:
Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase
Method: X-RAY DIFFRACTION / Resolution: 3.442 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-DCT:
2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE

ChemComp-DCP:
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsDNA Binding Protein/DNA / mitochondria / DNA polymerase holoenzyme / DNA Binding Protein-DNA complex / DNA polymerase / processivity / drug toxicity

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