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Structure paper

TitleThe flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response.
Journal, issue, pagesPlos One, Vol. 10, Page e0128222-e0128222, Year 2015
Publish dateJul 22, 2014 (structure data deposition date)
AuthorsIakovleva, I. / Begum, A. / Pokrzywa, M. / Walfridsson, M. / Sauer-Eriksson, A.E. / Olofsson, A.
External linksPlos One / PubMed:26020516
MethodsX-ray diffraction
Resolution1.12 - 1.7 Å
Structure data

PDB-4qxv:
CRYSTAL STRUCTURE of HUMAN TRANSTHYRETIN IN COMPLEX WITH LUTEOLIN AT 1.1 A RESOLUTION
Method: X-RAY DIFFRACTION / Resolution: 1.12 Å

PDB-4qya:
Crystal structure of human transthyretin variant V30M in complex with luteolin
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-LU2:
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one

ChemComp-GOL:
GLYCEROL

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / beta barrel / Wild type TTR / Transthyretin / AMYLOID FIBRILS / Vitamin A / Retinol-binding Protein

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