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TitleCamelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
Journal, issue, pagesMAbs, Vol. 7, Page 693-706, Year 2015
Publish dateSep 3, 2014 (structure data deposition date)
AuthorsKlarenbeek, A. / Mazouari, K.E. / Desmyter, A. / Blanchetot, C. / Hultberg, A. / de Jonge, N. / Roovers, R.C. / Cambillau, C. / Spinelli, S. / Del-Favero, J. ...Klarenbeek, A. / Mazouari, K.E. / Desmyter, A. / Blanchetot, C. / Hultberg, A. / de Jonge, N. / Roovers, R.C. / Cambillau, C. / Spinelli, S. / Del-Favero, J. / Verrips, T. / de Haard, H.J. / Achour, I.
External linksMAbs / PubMed:26018625
MethodsX-ray diffraction
Resolution1.746 - 3.31 Å
Structure data

PDB-4r90:
Anti CD70 Llama glama Fab 27B3
Method: X-RAY DIFFRACTION / Resolution: 1.746 Å

PDB-4r96:
Structure of a Llama Glama Fab 48A2 against human cMet
Method: X-RAY DIFFRACTION / Resolution: 3.31 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • llama glama (llama)
KeywordsIMMUNE SYSTEM / immunoglobulin fold / human CD70 / Immunoglobulin domains / cMet

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