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Structure paper

TitleHuman gamma-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS.
Journal, issue, pagesJ. Biol. Chem., Vol. 290, Page 17576-17586, Year 2015
Publish dateApr 10, 2015 (structure data deposition date)
AuthorsTerzyan, S.S. / Burgett, A.W. / Heroux, A. / Smith, C.A. / Mooers, B.H. / Hanigan, M.H.
External linksJ. Biol. Chem. / PubMed:26013825
MethodsX-ray diffraction
Resolution2.1 - 2.3 Å
Structure data

PDB-4z9o:
Crystal Structure of human GGT1
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-4zbk:
Crystal Structure of human GGT1 in complex with GGsTop inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.18 Å

PDB-4zc6:
Crystal Structure of human GGT1 in complex with Serine Borate
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4zcg:
Crystal Structure of human GGT1 in complex with Glutamate (with all atoms of glutamate)
Method: X-RAY DIFFRACTION / Resolution: 2.22 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-CL:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-4M8:
(2S)-2-amino-4-[(S)-hydroxy(methoxy)phosphoryl]butanoic acid

ChemComp-SEE:
trihydroxy(L-serinato-kappaO~3~)borate(1-)

ChemComp-GLU:
GLUTAMIC ACID

Source
  • homo sapiens (human)
KeywordsHYDROLASE / TRANSFERASE / NTN-HYDROLASE FAMILY / GLYCOPROTEIN / N- GLYCOSYLATION / CELL SURFACE / HYDROLASE/HYDROLASE INHIBITOR / ENZYME INHIBITOR COMPLEX / HYDROLASE-HYDROLASE INHIBITOR complex

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