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TitleRedesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.
Journal, issue, pagesJ. Clin. Invest., Vol. 125, Page 2523-2531, Year 2015
Publish dateFeb 17, 2015 (structure data deposition date)
AuthorsWillis, J.R. / Sapparapu, G. / Murrell, S. / Julien, J.P. / Singh, V. / King, H.G. / Xia, Y. / Pickens, J.A. / LaBranche, C.C. / Slaughter, J.C. ...Willis, J.R. / Sapparapu, G. / Murrell, S. / Julien, J.P. / Singh, V. / King, H.G. / Xia, Y. / Pickens, J.A. / LaBranche, C.C. / Slaughter, J.C. / Montefiori, D.C. / Wilson, I.A. / Meiler, J. / Crowe, J.E.
External linksJ. Clin. Invest. / PubMed:25985274
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-4yaq:
Crystal structure of a computationally optimized PG9 mutant
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Antibody / HIV

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