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TitleNovel Furin Inhibitors with Potent Anti-infectious Activity.
Journal, issue, pagesChemmedchem, Vol. 10, Page 1218-1231, Year 2015
Publish dateDec 15, 2014 (structure data deposition date)
AuthorsHardes, K. / Becker, G.L. / Lu, Y. / Dahms, S.O. / Kohler, S. / Beyer, W. / Sandvig, K. / Yamamoto, H. / Lindberg, I. / Walz, L. ...Hardes, K. / Becker, G.L. / Lu, Y. / Dahms, S.O. / Kohler, S. / Beyer, W. / Sandvig, K. / Yamamoto, H. / Lindberg, I. / Walz, L. / von Messling, V. / Than, M.E. / Garten, W. / Steinmetzer, T.
External linksChemmedchem / PubMed:25974265
MethodsX-ray diffraction
Resolution2.15 Å
Structure data

PDB-4ryd:
X-ray structure of human furin in complex with the competitive inhibitor para-guanidinomethyl-Phac-R-Tle-R-Amba
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-FMT:
FORMIC ACID

ChemComp-CA:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHydrolase/Hydrolase Inhibitor / competitive inhibitor / pro-protein convertase / serine protease / Hydrolase-Hydrolase Inhibitor complex

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