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Structure paper

TitleRoles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
Journal, issue, pagesJ. Biol. Chem., Vol. 290, Page 15921-15933, Year 2015
Publish dateMar 12, 2015 (structure data deposition date)
AuthorsSu, Y. / Patra, A. / Harp, J.M. / Egli, M. / Guengerich, F.P.
External linksJ. Biol. Chem. / PubMed:25947374
MethodsX-ray diffraction
Resolution1.78 - 2.064 Å
Structure data

PDB-4yp3:
Mutant Human DNA Polymerase Eta Q38A/R61A Inserting dCTP Opposite an 8-Oxoguanine Lesion
Method: X-RAY DIFFRACTION / Resolution: 1.89 Å

PDB-4yqw:
Mutant Human DNA Polymerase Eta Q38A/R61A Inserting dCTP Opposite Template G
Method: X-RAY DIFFRACTION / Resolution: 2.064 Å

PDB-4yr0:
Mutant Human DNA Polymerase Eta R61M Inserting dCTP Opposite an 8-Oxoguanine Lesion
Method: X-RAY DIFFRACTION / Resolution: 1.78 Å

PDB-4yr2:
Mutant Human DNA Polymerase Eta R61M Inserting dATP Opposite an 8-Oxoguanine Lesion
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-4yr3:
Mutant Human DNA Polymerase Eta R61M Inserting dCTP Opposite Template G
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-DCP:
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE

ChemComp-CA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-DTP:
2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTransferase/DNA / Human DNA polymerase eta Q38A/R61A mutation 8-oxoguanine dCTP / Transferase-DNA complex / dCTP Template G / dCTP 8-Oxoguanine / dATP 8-Oxoguanine

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