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-Structure paper
Title | A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. |
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Journal, issue, pages | Nat. Chem. Biol., Vol. 11, Page 432-437, Year 2015 |
Publish date | Dec 6, 2014 (structure data deposition date) |
![]() | Chan-Penebre, E. / Kuplast, K.G. / Majer, C.R. / Boriack-Sjodin, P.A. / Wigle, T.J. / Johnston, L.D. / Rioux, N. / Munchhof, M.J. / Jin, L. / Jacques, S.L. ...Chan-Penebre, E. / Kuplast, K.G. / Majer, C.R. / Boriack-Sjodin, P.A. / Wigle, T.J. / Johnston, L.D. / Rioux, N. / Munchhof, M.J. / Jin, L. / Jacques, S.L. / West, K.A. / Lingaraj, T. / Stickland, K. / Ribich, S.A. / Raimondi, A. / Scott, M.P. / Waters, N.J. / Pollock, R.M. / Smith, J.J. / Barbash, O. / Pappalardi, M. / Ho, T.F. / Nurse, K. / Oza, K.P. / Gallagher, K.T. / Kruger, R. / Moyer, M.P. / Copeland, R.A. / Chesworth, R. / Duncan, K.W. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.35 - 3.05 Å |
Structure data | ![]() PDB-4x60: ![]() PDB-4x61: ![]() PDB-4x63: |
Chemicals | ![]() ChemComp-SFG: ![]() ChemComp-3XV: ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-SAM: ![]() ChemComp-SAH: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / protein-inhibitor complex / protein arginine methyltransferase / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX |