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TitleThe Discovery and Characterization of the alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N-{(3S,4S)-4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242).
Journal, issue, pagesJ. Med. Chem., Vol. 58, Page 4291-4308, Year 2015
Publish dateDec 2, 2014 (structure data deposition date)
AuthorsShaffer, C.L. / Patel, N.C. / Schwarz, J. / Scialis, R.J. / Wei, Y. / Hou, X.J. / Xie, L. / Karki, K. / Bryce, D.K. / Osgood, S.M. ...Shaffer, C.L. / Patel, N.C. / Schwarz, J. / Scialis, R.J. / Wei, Y. / Hou, X.J. / Xie, L. / Karki, K. / Bryce, D.K. / Osgood, S.M. / Hoffmann, W.E. / Lazzaro, J.T. / Chang, C. / McGinnis, D.F. / Lotarski, S.M. / Liu, J. / Obach, R.S. / Weber, M.L. / Chen, L. / Zasadny, K.R. / Seymour, P.A. / Schmidt, C.J. / Hajos, M. / Hurst, R.S. / Pandit, J. / O'Donnell, C.J.
External linksJ. Med. Chem. / PubMed:25905800
MethodsX-ray diffraction
Resolution1.89 Å
Structure data

PDB-4x48:
Crystal structure of GluR2 ligand-binding core
Method: X-RAY DIFFRACTION / Resolution: 1.89 Å

Chemicals

ChemComp-GLU:
GLUTAMIC ACID

ChemComp-ZN:
Unknown entry

ChemComp-XPF:
N-{(3S,4S)-4-[4-(5-cyanothiophen-2-yl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsMEMBRANE PROTEIN / AMPA receptor / allosteric modulator

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