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Structure paper

TitleStructural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.
Journal, issue, pagesNat Commun, Vol. 6, Page 6481-6481, Year 2015
Publish dateSep 2, 2014 (structure data deposition date)
AuthorsYatime, L. / Maasch, C. / Hoehlig, K. / Klussmann, S. / Andersen, G.R. / Vater, A.
External linksNat Commun / PubMed:25901944
MethodsX-ray diffraction
Resolution1.8 - 2 Å
Structure data

PDB-4wb2:
Crystal structure of the mirror-image L-RNA/L-DNA aptamer NOX-D20 in complex with mouse C5a complement anaphylatoxin
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-4wb3:
Crystal structure of the mirror-image L-RNA/L-DNA aptamer NOX-D20 in complex with mouse C5a-desArg complement anaphylatoxin
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-CA:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • synthetic construct (others)
KeywordsDNA-RNA HYBRID / protein-RNA complex / mirror-image aptamer / G-quadruplex / complement anaphylatoxin

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