タイトル | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. |
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ジャーナル・号・ページ | Chemmedchem, Vol. 10, Page 1232-1239, Year 2015 |
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掲載日 | 2014年7月24日 (構造データの登録日) |
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著者 | Holvey, R.S. / Valkov, E. / Neal, D. / Stewart, M. / Abell, C. |
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リンク | Chemmedchem / PubMed:25899172 |
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手法 | X線回折 |
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解像度 | 1.96 - 2.56 Å |
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構造データ | PDB-4u54: IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 2.41 Å PDB-4u58: IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 2.56 Å PDB-4u5l: IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 2.53 Å PDB-4u5n: IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 2.31 Å PDB-4u5o: IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-4u5s: IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 2.12 Å PDB-4u5u: IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 1.96 Å PDB-4u5v: IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 1.968 Å |
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化合物 | ChemComp-3C5: N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine
ChemComp-3C6: N~2~-[4-(pyridin-3-yl)benzoyl]-L-lysinamide
ChemComp-3D6: N~2~-[4-(pyridin-3-yl)benzyl]-L-lysinamide
ChemComp-3D4: N~2~-[4-(pyridin-3-yl)benzyl]-L-lysyl-N-[(1R,2S,3R)-1-{[(2R)-1-amino-1-oxo-3-phenylpropan-2-yl]amino}-1,3-dihydroxybutan-2-yl]glycinamide
ChemComp-3D5: N~2~-[4-(pyridin-3-yl)benzyl]-D-lysinamide
ChemComp-3D0: N-[(2S)-2-[(N~2~-acetyl-D-lysyl)amino]-3-(pyridin-3-ylmethoxy)propyl]-L-allothreonyl-D-phenylalaninamide
ChemComp-3D2: N~2~-[3-(pyridin-3-yl)benzyl]-L-lysinamide
ChemComp-RH2: N~2~-{[5-(pyridin-3-yl)thiophen-2-yl]methyl}-L-lysinamide
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由来 | - mus musculus (ハツカネズミ)
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キーワード | TRANSPORT PROTEIN / TPX2 inhibitor / TPX2 / inhibitor / importin-alpha / TPX2. inhibitor / minor site |
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