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Structure paper

TitleCatalytic mechanism of a retinoid isomerase essential for vertebrate vision.
Journal, issue, pagesNat. Chem. Biol., Vol. 11, Page 409-415, Year 2015
Publish dateNov 7, 2014 (structure data deposition date)
AuthorsKiser, P.D. / Zhang, J. / Badiee, M. / Li, Q. / Shi, W. / Sui, X. / Golczak, M. / Tochtrop, G.P. / Palczewski, K.
External linksNat. Chem. Biol. / PubMed:25894083
MethodsX-ray diffraction
Resolution1.8 - 2.39 Å
Structure data

PDB-4rsc:
Crystal structure of RPE65 in complex with emixustat and palmitate
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-4rse:
Crystal structure of RPE65 in complex with MB-001 and palmitate
Method: X-RAY DIFFRACTION / Resolution: 2.39 Å

Chemicals

ChemComp-FE2:
Unknown entry

ChemComp-PLM:
PALMITIC ACID

ChemComp-A3V:
(1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol

ChemComp-HOH:
WATER

ChemComp-A6V:
(1R)-3-amino-1-{3-[(2,6,6-trimethylcyclohex-1-en-1-yl)methoxy]phenyl}propan-1-ol

Source
  • bos taurus (domestic cattle)
KeywordsISOMERASE / 7-bladed beta propeller / monotopic membrane protein / non-heme iron enzyme / retinoid isomerase / smooth endoplasmic reticulum

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